What is kratom and what are the benefits?

The most common uses of it are to relieve pain, depression, and opioid addiction. The two most active compounds found in kratom, mitragynine and 7-hydroxymitragynine, work on opioid receptors, but with fewer side effects. Kratom has been used for hundreds of years in Asia as a natural home remedy.

What is Mitragyna speciosa kratom used for?

Kratom (Mitragyna speciosa) is a tree native to Southeast Asia. The leaves contain a chemical called mitragynine, which works like opioids such as morphine. Kratom has pain-relieving effects like opioid drugs. It also has many of the same serious safety concerns as other opioids.

What is kratom in Thai?

Thailand has decriminalized the possession and sale of kratom, a plant that’s native to Southeast Asia whose leaves are used as a mild stimulant and painkiller. ByChalida Ekvitthayavechnukul Associated Press. August 24, 2021, 5:09 AM. 3:49. On Location: June 10, 2022.

Which neurotransmitters does kratom affect?

While kratom is most commonly known for its affinity to opioid receptors, it also has affinity to serotonin and dopamine receptors [13,14], signaling its potential for treating depression, anxiety, and psychosis.

Will kratom hurt your liver?

Hepatotoxicity. Chronic use of kratom recreationally has been associated with rare instances of acute liver injury. The onset of injury is usually within 1 to 8 weeks of starting regular use of kratom powder or tablets, with symptoms of fatigue, nausea, pruritus and dark urine followed by jaundice.

Can kratom hurt your heart?

Other serious kratom side effects include: Cardiac issues, such as heart attack, abnormal heart rhythms and high blood pressure.

How strong is mitragynine?

Mitragynine pseudoindoxyl was 3-fold more potent than morphine, and 7-hydroxymitragyinine was 5-fold more potent than morphine. Advantageously, mitragynine pseudoindoxyl caused less tolerance, respiratory depression, and inhibition of gastrointestinal motility than equianalgesic doses of morphine.

Which country uses kratom?

It is indigenous to Thailand, Indonesia, Malaysia, Myanmar, and Papua New Guinea, where it has been used in herbal medicine since at least the nineteenth century. Kratom has opioid properties and some stimulant-like effects. (Korth.)

Can kratom damage the brain?

Kratom has become a popular recreational drug in the West. Kratom works as a stimulant but at high doses it has sedative/anti-nociceptive effects. Kratom abuse may be associated with structural brain lesions on MRI.

Can you get serotonin syndrome from kratom?

A case of a mixed overdose involving kratom (Mitragyna speciosa) leading to serotonin syndrome | Medical Science and Discovery.

What drugs interact with kratom?

To date several case studies of drug interactions with Kratom have been reported that relate to its CNS depressant effects. Both additive and synergistic effects are observed if Kratom is used with benzodiazepines, barbiturates, alcohol, opioids, antidepressants, anxiolytics, and other CNS-active drugs [18].

Does kratom affect your liver?

Chronic use of kratom recreationally has been associated with rare instances of acute liver injury. The onset of injury is usually within 1 to 8 weeks of starting regular use of kratom powder or tablets, with symptoms of fatigue, nausea, pruritus and dark urine followed by jaundice.

How strong is 7 mitragynine?

Consistent with previous reports,22,25 it was found that 7-OH was a highly potent analgesic (ED50 = 0.6 mg/kg, s.c.), ∼fivefold more potent than p.o. mitragynine.

What kratom has the highest alkaloid content?

Mitragynine is the most abundant alkaloid in the leaves.

How many kratom leaves a day?

A common route of administration is by chewing the fresh leaves at a dosage of normally 10 to 30 leaves per day. Kratom can be ingested as crushed dried leaves by taking powder, drinking as a tea or by smoking the leaves or the extract [71].

Is kratom hard on the liver?

Can kratom cause permanent psychosis?

Kratom consumption can lead to addiction. Several cases of psychosis resulting from use of kratom have been reported, where individuals addicted to kratom exhibited psychotic symptoms, including hallucinations, delusion, and confusion.

Does kratom cause heart palpitations?

A few case reports also speculatively suggested that kratom consumption may have induced ventricular arrhythmia, particularly ventricular tachycardia and fibrillation, resulting in cardiopulmonary arrest.

Does kratom cause brain swelling?

Glatter says side effects of kratom include seizures, dangerously high blood pressure, damage to liver and kidneys, swelling of the brain, breathing problems, and cardiac arrest. The chances of these problems are even higher when people use kratom with alcohol or with other drugs, he says.