What is the chemical structure for atorvastatin?

C33H35FN2O5Atorvastatin / Formula

How is atorvastatin metabolised?

Atorvastatin acid is extensively metabolised in both the gut and liver by oxidation, lactonisation and glucuronidation, and the metabolites are eliminated by biliary secretion and direct secretion from blood to the intestine.

What is the mechanism of action for atorvastatin?

Mechanism of Action Atorvastatin competitively inhibits 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. [2] By preventing the conversion of HMG-CoA to mevalonate, statin medications decrease cholesterol production in the liver.

How do statins mechanism of action?

Mechanism of Action Statins work by competitively blocking the active site of the first and key rate-limiting enzyme in the mevalonate pathway, HMG-CoA reductase. Inhibition of this site prevents substrate access, thereby blocking the conversion of HMG-CoA to mevalonic acid.

How does atorvastatin mechanism of action?

What is the primary mechanism of action of statin drugs?

Statins act by competitively inhibiting HMG-CoA reductase, the rate-limiting enzyme of the mevalonate pathway. Because statins are similar in structure to HMG-CoA on a molecular level, they will fit into the enzyme’s active site and compete with the native substrate (HMG-CoA).

How does atorvastatin inhibit HMG-CoA reductase?

Statins competitively inhibit the HMG-CoA reductase enzyme. Statins bind to the active site of the enzyme and change its structure. As the structure of the enzyme is changed, it cannot bind with the receptor, thus its activity is reduced.

How does atorvastatin work in the body?

Atorvastatin is in a class of medications called HMG-CoA reductase inhibitors (statins). It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.

How do statins work HMG-CoA reductase?

Statins act by competitively binding to the catalytic domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase, HMGCR)8,9 and blocking the conversion of HMG-CoA to mevalonate, the rate-limiting step of cholesterol biosynthesis.

Which of the following best describes statins mechanism of action?

HMG-CoA reductase inhibition is the mechanism of action of statins.

What is the mechanism of action of atorvastatin?

What regulates the activity of HMG-CoA reductase the fastest?

The enzyme activity is regulated at the transcriptional level, that is, by changing the rate of synthesis of the mRNA encoding the enzyme. HMG-CoA reductase is regulated by phosphorylation and dephosphorylation also.

How do statins work pharmacology?

Statins, inhibitors of the hydroxymethylglutaryl-CoA (HMG-CoA) reductase enzyme, are molecules of fungal origin. By inhibiting a key step in the sterol biosynthetic pathway statins are powerful cholesterol lowering medications and have provided outstanding contributions to the prevention of cardiovascular disease.

How do statins work mechanism of action?

How is the activity of HMG-CoA reductase regulated?

Regulated Degradation of HMG-CoA Reductase The activity of the enzyme is regulated by changes in transcription, translation (mechanism unknown) and protein stability.

How do statins work mechanism?

Do all statins have the same mechanism of action?

Despite having the same mechanism of action and comparative effects on cholesterol profiles, statins can still be subdivided into one of two categories: type I, fungal-derived statins (lovastatin, pravastatin, simvastatin); or type II, synthetically-derived statins (fluvastatin, cerivastatin, atorvastatin, rosuvastatin …

What is the mechanism of action of statins HMG-CoA reductase inhibitors?

Also known as statins, HMG-CoA reductase inhibitors work by inhibiting the synthesis of cholesterol in the liver by the enzyme HMG-CoA reductase.