How does Celexa react with alcohol?

Celexa does not magnify the effects of alcohol. However, alcohol can worsen the side effects or the risks associated with taking Celexa and can lead to overdose or other severe health problems. You should not drink alcohol while you are taking Celexa.

How is Celexa metabolized?

Citalopram is metabolized mainly in the liver via N-demethylation to its main metabolite, demethylcitalopram by CYP2C19 and CYP3A4 7. Other metabolites include didemethylcitalopram via CYP2D6 metabolism, and citalopram N-oxide via monoamine oxidase enzymes and aldehyde oxidase.

Is citalopram an organic molecule?

Structure for FDB023605 (Citalopram) Belongs to the class of organic compounds known as phenylbutylamines. Phenylbutylamines are compounds containing a phenylbutylamine moiety, which consists of a phenyl group substituted at the fourth carbon by an butan-1-amine.

Is citalopram an enzyme inhibitor?

Citalopram and escitalopram are weak CYP2D6 inhibitors [30–32] and have weak or no effect on CYP1A2, CYP2C19, and CYP3A4 [30].

What drugs does Celexa interact with?

Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication.

What happens if you drink alcohol while taking Lexapro?

You may think of alcohol as something to lift your mood, but mixing it and Lexapro may actually do the opposite: Alcohol can make your depression worse. You may not want to risk feeling even more depressed or anxious than you were before you took an antidepressant.

Is citalopram a CYP2C19 inhibitor?

Citalopram produces mild inhibition of CYP2D6. Fluvoxamine produces inhibition (which would be expected to be clinically meaningful) of two CYP enzymes. CYP1A2 and CYP2C19, and probably a third, CYP3A3/4.

Is Celexa metabolized by the liver?

Citalopram and escitalopram are extensively metabolized by the liver, mainly via the cytochrome P450 system (CYP 3A4, 2D6 and 2C19) and hepatotoxicity may be mediated by toxic intermediates of their metabolism.

What is Celexa made of?

Celexa oral solution contains citalopram HBr equivalent to 2 mg/mL citalopram base. It also contains the following inactive ingredients: sorbitol, purified water, propylene glycol, methylparaben, natural peppermint flavor, and propylparaben.

What functional groups are in citalopram?

More specifically, citalopram contains a tertiary amine along with a tetrahydrofuran ring fused to a cyano-substituted benzene ring. The remainder of the molecule consists of a 4-fluorobenzene ring connected so as to create a chiral centre (denoted * in Figure 1).

Is citalopram a CYP2D6 substrate?

The impact of CYP2D6 activity in drug metabolism is further complicated by the activity of the drug itself on CYP2D6. Some SSRIs, such as paroxetine, fluoxetine, and citalopram, as well as statins, are known to inhibit CYP2D6 activity and may make EMs resemble IMs or PMs.

What drugs should not be taken with Celexa?

Do not use citalopram with buspirone (Buspar®), fentanyl (Abstral®, Duragesic®), lithium (Eskalith®, Lithobid®), methylene blue injection, tryptophan, St John’s wort, amphetamines, or some pain or migraine medicines (eg, rizatriptan, sumatriptan, tramadol, Frova®, Imitrex®, Maxalt®, Relpax®, Ultram®, Zomig®).

Who should not take Celexa?

Citalopram use is discouraged in patients with congenital long QT syndrome. Patients with low levels of potassium and magnesium in the blood are also at increased risk. If you are currently taking citalopram at a dose greater than 40 mg per days, talk to your health care professional.

Is citalopram metabolized by CYP2D6?

Citalopram is metabolized by three CYP enzymes. CYP2C19 and CYP3A4 play a primary role in citalopram metabolism, whereas CYP2D6 plays a secondary role.

Which antidepressants are metabolized by CYP2C19?

In this study we focus on the SSRIs: sertraline, escitalopram and citalopram as they are reported to be extensively metabolized by CYP2C19 [13].

Can citalopram cause elevated liver enzymes?

People with liver disease: Citalopram is processed by your liver. If you have liver problems, the levels of this drug in your body might increase. You may have more side effects People with liver disease shouldn’t take more than 20 mg of citalopram once per day.

Can you have alcohol while taking citalopram?

You can drink alcohol while taking citalopram, but it may make you feel sleepy. It might be best to stop drinking alcohol until you see how the medicine makes you feel.

How is citalopram synthesized?

Synthesis of citalopram is proposed to occur by two general routes, usually called the anion strategy and the double Grignard strategy (Scheme 7.12.). Scheme 7.12. Synthesis of citalopram and escitalopram. In both cases, synthesis is started from a reaction of phthalide (7.3.