What are side effects of domperidone?

Side Effects

• swelling of the ankles/feet.
• unusual tiredness.
• mental/mood changes (e.g., nervousness, irritability)
• hot flashes.
• breast swelling/pain.
• unusual leakage of milk from the breast.
• changes in menstrual periods.
• decreased sexual ability.

What drugs should not be taken with domperidone?

Certain medications (e.g., sotalol, quinidine, thioridazine, chlorpromazine, pimozide, moxifloxacin, mefloquine, pentamidine, arsenic trioxide, ondansetron, probucol, tacrolimus) can increase the risk of a type of abnormal heart rhythm called QT prolongation, and should not be used in combination with domperidone if …

When is domperidone contraindicated?

Domperidone is now contraindicated in people: with conditions where cardiac conduction is, or could be, impaired. with underlying cardiac diseases such as congestive heart failure. receiving other medications known to prolong QT interval or potent CYP3A4 inhibitors.

How does domperidone affect the heart?

It is already known that domperidone can cause irregular heartbeats (heart arrhythmia). A recent review of the safety and effectiveness of domperidone found that it may slightly increase the risk of an irregular heartbeat and death due to heart problems.

Does domperidone raise blood pressure?

Conclusion: Domperidone increases blood pressure and heart rate without inducing nocturnal hypertension in apomorphine treated patients with idiopathic Parkinson’s disease. Increased heart rate by domperidone is a new finding but the clinical significance is unclear and requires further investigation.

Can domperidone cause palpitations?

If you experience any symptoms of abnormal heart rhythms such as dizziness, fainting or heart palpitations while you are taking domperidone, you should stop taking this medicine and seek medical attention.

What is a known CNS brain side effects of domperidone?

Nausea and Vomiting Domperidone’s major adverse effect is prolongation of the QTc interval, which has been attributed to its inhibitory effect on the hERG channel (Whiting et al., 2021), and lead to concerns regarding cardiac arrhythmia, cardiac arrest and sudden cardiac death.

Can domperidone cause high blood pressure?

Does domperidone lower blood pressure?

Can domperidone cause liver problems?

Liver disease Domperidone should be used with extreme caution if you have liver problems due to the increased risk of serious adverse effects and worsening your condition. Your doctor may monitor your liver function and may adjust the dose of this medicine if required based on your condition.

Does domperidone raise BP?

How safe is domperidone?

The FDA has issued a warning that using domperidone can cause an uneven heartbeat called cardiac arrhythmia. It can also cause cardiac arrest, which is a heart attack, and even sudden death. These serious dangers are related to the amount of domperidone that you take.

Can domperidone cause shortness of breath?

you have an allergic reaction to Domperidone (allergy can be recognised, for instance, by skin rash, itching, shortness of breath and/or swelling of the face, lips, mouth, tongue or throat which may cause difficulty in swallowing or breathing). Other side effects not listed above may also occur in some people.

Does domperidone cause extrapyramidal side effects?

Domperidone is a commonly prescribed antiemetic drug but its side effects are rarely seen. Extrapyramidal side effects are a very rare complication of the drug occurring in 1/10 000 population. They usually occur in infants and very young children due to a poorly developed blood–brain barrier.

Can domperidone cause sleepiness?

Domperidone belongs to a group of anti-sickness medicines called anti-emetics. Anti-emetics work in a similar way to each other. However, domperidone is less likely to make you feel tired. There are other medicines that can help with sickness.

Is domperidone safe for kidneys?

Domperidone, metoclopramide, and prochlorperazine are not significantly renally cleared and can be used in CKD; however, extrapyramidal and CNS effects may be more prevalent, especially in high dose. Dosing should be cautiously titrated to effect.

Does domperidone increase blood pressure?

Does domperidone cause anxiety?

Rarely domperidone may cause muscle/nervous system problems (EPS). Tell your doctor right away if any of these rare but serious side effects occur: feelings of anxiety/agitation/jitteriness. trouble swallowing.